HORDB

ID: hor006143
Uniprot ID: P23389
Protein name: Secretolytin
Gene name: CHGB
Organism: Bos taurus (Bovine)
Family: Chromogranin/secretogranin protein family
Source: animal
Expression: NA
Disease: NA
Comments: NA
Taxonomy: Bos (genus), Bovinae (subfamily), Bovidae (family), Pecora (infraorder), Ruminantia (suborder), Artiodactyla (order), Laurasiatheria (superorder), Boreoeutheria, Eutheria, Theria, Mammalia (class), Amniota, Tetrapoda, Dipnotetrapodomorpha, Sarcopterygii (superclass), Euteleostomi, Teleostomi, Gnathostomata, Vertebrata, Craniata (subphylum), Chordata (phylum), Deuterostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
GO MF: NA
GO BP: NA
GO CC: GO:0005576 extracellular region; GO:0005615 extracellular space; GO:0016020 membrane; GO:0030141 secretory granule; GO:0030658 transport vesicle membrane; GO:0031410 cytoplasmic vesicle

Sequence: DLELQKIAEKFSGTRRG
Length: 17
Propeptide: MQPAALLGLLGATVVAAVSSMPVDIRNHNEEVVTHCIIEVLSNALLKSSAPPITPECRQVLKKNGKELKNEEKSENENTRFEVRLLRDPADTSEAPGLSSREDSGEGDAQVPTVADTESGGHSRERAGEPPGSQVAKEAKTRYSKSEGQNREEEMVKYQKRERGEVGSEERLSEGPGKAQTAFLNQRNQTPAKKEELVSRYDTQSARGLEKSHSRERSSQESGEETKSQENWPQELQRHPEGQEAPGESEEDASPEVDKRHSRPRHHHGRSRPDRSSQEGNPPLEEESHVGTGNSDEEKARHPAHFRALEEGAEYGEEVRRHSAAQAPGDLQGARFGGRGRGEHQALRRPSEESLEQENKRHGLSPDLNMAQGYSEESEEERGPAPGPSYRARGGEAAAYSTLGQTDEKRFLGETHHRVQESQRDKARRRLPGELRNYLDYGEEKGEEAARGKWQPQGDPRDADENREEARLRGKQYAPHHITEKRLGELLNPFYDPSQWKSSRFERKDPMDDSFLEGEEENGLTLNEKNFFPEYNYDWWEKKPFEEDVNWGYEKRNPVPKLDLKRQYDRVAELDQLLHYRKKSAEFPDFYDSEEQMSPQHTAENEEEKAGQGVLTEEEEKELENLAAMDLELQKIAEKFSGTRRG
Signal peptide: MQPAALLGLLGATVVAAVSS
Modification: T5 Pyrrolidone carboxylic acid
Glycosylation: NA
Mutagenesis: NA

Function: Secretogranin-1 is a neuroendocrine secretory granule protein, which may be the precursor for other biologically active peptides. The 16 pairs of basic AA distributed throughout its sequence may be used as proteolytic cleavage sites.; Secretolytin has antibacterial activity.
Mechanism: NA
Cross BBB: NA
Target: NA
Target Unid: NA
IC50: NA
EC50: NA
ED50: NA
kd: NA
Half life: NA

Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)

hor006143_AF2.pdb

hor006143_ESM.pdb

Mass:	223378	Formula:	C84H142N26O27
Absent amino acids:	CHMNPVWY	Common amino acids:	EGKLR
pI:	9.53	Basic residues:	4
Polar residues:	4	Hydrophobic residues:	5
Hydrophobicity:	-96.47	Boman Index:	-5336
Half-Life:	1.1 hour	Half-Life Yeast:	3 min
Half-Life E.Coli:	>10 hour	Aliphatic Index	74.71
Instability Index:	4730	Extinction Coefficient cystines:	0
Absorbance 280nm:	0

PubMed ID: 2025642
Title: Primary structure of bovine chromogranin B deduced from cDNA sequence.
PubMed ID: 9136897
Title: Identification of the secretory vesicle membrane binding region of chromogranin B.
PubMed ID: 1350945
Title: Nucleotide and deduced amino acid sequence of bovine adrenal medulla chromogranin B (secretogranin I).
PubMed ID: 8218367
Title: pH-dependent binding of chromogranin B and secretory vesicle matrix proteins to the vesicle membrane.
PubMed ID: 1554736
Title: Mass spectrometric characterization of bovine chromaffin granule peptides related to chromogranin B.
PubMed ID: 1982622
Title: A novel 1745-dalton pyroglutamyl peptide derived from chromogranin B is in the bovine adrenomedullary chromaffin vesicle.
PubMed ID: 7744058
Title: Processing of chromogranin B in bovine adrenal medulla. Identification of secretolytin, the endogenous C-terminal fragment of residues 614-626 with antibacterial activity.
PubMed ID: 15174145
Title: Characterization and location of post-translational modifications on chromogranin B from bovine adrenal medullary chromaffin granules.
PubMed ID: 8603705
Title: Antibacterial activity of secretolytin, a chromogranin B-derived peptide (614-626), is correlated with peptide structure.